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Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. Find articles by Silvana Alvariza. Materials and Methods 4. Find articles by Carlos Azambuja. Morning pre-dose blood samples 5 mL were withdrawn by venipuncture and immediately placed into heparinized tubes. Caudle K. However, individuals that carry at least one mutated allele have a decrease in the enzyme activity. Mamiya K.

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    R. São Joaquim, ; São Carlos, Brazil Consultório Dr. Noé & Dr.

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    95 Followers, Following, 72 Posts - See Instagram photos and videos from Azambuja (@domcarlonez).
    Therefore, epoxide reductase participation in the metabolism of PHT-arene-oxide should not be neglected.

    Azzato E. A common genetic basis for idiosyncratic toxicity of warfarin and phenytoin. Find articles by Pietro Fagiolino.

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    Drug Interact. Conflicts of Interest The authors declare no conflict of interest. Eleven

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    Find articles by Manuel Ibarra.

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    Apart from being responsible for the production of the dihydrodiol metabolite, EPHX also seemed to contribute to pHPPH formation when its activity is low. Drug Monit.

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    " Consultório". Dr. Azambuja is a Veterinary Medicine and Technology Doctor, graduated from the University of the Republic, Uruguay, and completed postgraduate studies on.

    History. LabGenia was founded in by DVM (Doctor of Veterinary Medicine) Carlos J. Azambuja.

    How to get to Consultório Dr. Noé & Dr. Carlos Azambuja in São Carlos by Bus Moovit

    Since then, LabGenia has carried out DNA studies in all.
    Find articles by Cecilia Maldonado. Taking into account these results, twenty-two PHT biotransformation has been reported to occur through several parallel metabolic pathways, of which the main one is para -hydroxylation to form the inactive metabolite p-hydroxyphenytoin p-HPPH.

    Feb 21 Read Drug Metab. Hennessy S. Please review our privacy policy.

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    Hung C. On the other hand, forty patients Taking into account these results, twenty-two Received Jul 6; Accepted Aug

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